What are the side effects of metformin and glyburide?
• A: According to the research on metformin, side effects with greater than 5% incident include, diarrhea (53%), nausea/vomiting (25%), flatulence (12%), asthenia (9%), indigestion (7%), abdominal discomfort (6%) and headache (6%). The main concern with metformin over long-term therapy is accumulation of metformin leading to lactic acidosis (too much lactic acid in the blood). Lactic acidosis is very rare but can be fatal. Lactic acidosis usually results in patients who have poor renal function because metformin can’t be excreted. Lactic acidosis can also be caused by poor liver function because the liver can’t excrete lactic acid. Liver and kidney failure can result from other conditions such as aging, cancer and excessive alcohol consumption. It is therefore imperative that patients be monitored for decreasing kidney and liver function. It is also important to notify the physician if you notice symptoms of lactic acidosis. Symptoms may include feeling weak, tired, unusual muscle pain