What can behavior genetic research contribute to the search for vulnerability genes?
Behavior genetic studies have much to offer beyond establishing heritability. Strong doubts were expressed about the readiness of the drug abuse field at this time to mount a successful candidate gene search. Many issues need to be further resolved first, to which behavior genetics, or genetic epidemiology, can contribute. In fact, the relationship between heritability and gene localization is termed “loose.” Behavior genetics can contribute to definition of preclinical phenotypes. In fact, a recommendation was made to study low exposure dependent individuals, and relatives with related deficits who don’t meet full dependence criteria, rather than confining the studies to high exposure and heavily dependent individuals and family members. Genetically informed typological research is urged. Behavior genetics can play two roles: to inform molecular studies about sample selection (phenotype issues), and to refine and guide what needs to be measured after the population is selected. The dr
