What causes aortic valve regurgitation?
About half of the cases of aortic insufficiency are due to the aortic root dilatation, which has no known cause in over 80% of cases, but otherwise occurs with aging and hypertension, Marfan syndrome, aortic dissection, and syphilis. In about 15% the cause is innate bicuspidal aortic valve, while another 15% cases are due to complications from diseases such as rheumatic fever.
