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What criteria are used to annotate gene products to GO:0009405 : pathogenesis?

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What criteria are used to annotate gene products to GO:0009405 : pathogenesis?

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The term GO:0009405 : pathogenesis is defined as “The set of specific processes that generate the ability of an organism to cause disease in another”. In the Pto-Plant Interaction Model, effectors are annotated to this term when they have a demonstrated role in symptom production or suppression of plant defense.

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