What do I advise for a traveller with glucose 6-phosphate dehydrogenase (G6PD) deficiency?
A. Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme in the hexose monophosphate shunt of the glycolytic pathway. This shunt supports the red cells protection against oxidative damage. Absence of G6PD renders the red cell liable to haemolysis in the presence of some drugs. The most common G6PD deficiency allele in Africa (G6PD A-) has been shown to confer some resistance to malaria in both hemizygous males and heterozygous females . Nevertheless, all G6PD-deficient travellers to malarious areas still require appropriate malaria prevention tablets. Chloroquine There is a theoretical risk of haemolysis in some G6PD-deficient individuals who receive chloroquine. This risk is acceptable in acute malaria  and G6PD levels are not usually checked before using chloroquine in treatment doses. Haemolysis does not appear to be a problem when chloroquine is given in the dose recommended for malaria prevention so there is no need to withhold chloroquine prophylaxis from those known to be