What does it mean and how valid are claims for synergy between antitumor agents?
A. Ocana, C. Yeung and I. Tannock AECC Cancer Research Unit, Albacete University Hospital, Albacete, Spain; Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada Abstract 6082 Background: Clinical trials evaluating drug combinations are often stimulated by claims that the agents are synergistic in preclinical models. Overuse or misuse of the term synergy could lead to evaluation of nonrational drug combinations and to poorly-designed clinical studies. Here we identified reports of clinical trials that contained the term “synergy” and reviewed the preclinical data used to justify evaluation of a drug combination. Methods: We reviewed MEDLINE using the terms “synergy and cancer” with the limits of “human” and “clinical trials” to select 96 articles published between 2003 and 2009. Eligible studies were those that referred to synergy in preclinical studies to justify the drug combination evaluated. We then reviewed the cited
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