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What does it mean if a patient has troublesome high values in the “intact” PTH assay that cannot be suppressed with vitamin D?

April 26, 2017assay high intact mean patient Pth suppressed troublesome values vitamin d

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What does it mean if a patient has troublesome high values in the “intact” PTH assay that cannot be suppressed with vitamin D?

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The “intact” PTH assay value is made up of CAP (1-84 PTH) and CIP (7-84 PTH). It is important to find out if the proportion of CAP (1-84 PTH) is much higher than CIP (7-84 PTH). If the proportion of CAP (1-84 PTH) is less than CIP (7-84 PTH), although “intact” PTH may be high, the patient may be over-suppressed. (ref. Slatopolsky et. al., Kidney International 2000; Vol.58:753-761. Monier-Faugere, Malluche, et.