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What drugs should not be taken with donepezil (Aricept)?

April 26, 2017Aricept donepezil drugs

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What drugs should not be taken with donepezil (Aricept)?

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A. Donepezil has been shown to interact with very few other drugs. However, it should not be taken with other cholinesterase inhibitors such as tacrine (Cognex) or with anticholinergic drugs, such as trihexyphenidyl HCl (Artane) and benztropine meyslate (Cogentin), that fight the effects of deonepezil. Interactions with other drugs that have anticholinergic side effects, such as amitriptyline or thorazine, should also be avoided.