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What effects does histamine have on the cardiovascular system?

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What effects does histamine have on the cardiovascular system?

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Evidence suggests that central histaminergic neurons make important contributions to cardiovascular regulation. For example, histamine-containing neurons project to brain regions important for cardiovascular regulation. Furthermore, stimulation of central histamine receptors changes blood pressure and heart rate and alters activity of major vasoconstrictor systems. Finally, histamine metabolism is changed in hypertension.

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