What genes are related to breast cancer?
Variations of the ATM, BRCA1, BRCA2, CHEK2, and RAD51 genes increase the risk of developing breast cancer. The AR, DIRAS3, ERBB2, and TP53 genes are associated with breast cancer. These genes provide instructions for making proteins that help regulate the growth and division of cells. Some of these proteins are involved in detecting and repairing damaged DNA. Others help the cell respond to external signals, such as hormones and growth factors. When a gene mutation alters the structure or function of these proteins, cells in the breast can grow and divide uncontrollably and form a tumor. BRCA1 and BRCA2 are major genes related to hereditary breast cancer. People who have inherited certain mutations in these genes have a high risk of developing breast cancer, ovarian cancer, and several other types of cancer over their lifetimes. Men with BRCA1 mutations have an increased risk of developing prostate cancer. Mutations in the BRCA2 gene are associated with an increased chance of developin
