What happens if I remove the Memory Stick Duo media from my PSP system while playing a game?
As a rule, it is not recommended to remove and re-insert the Memory Stick Duo media in the middle of playing a game. You may lose valuable data if you remove the Memory Stick Duo media while the access indicator is ON, unplug the device, or enter the sleep mode while playing. If necessary due to the low capacity, for example, you can remove the Memory Stick Duo media as long as data writing/reading is not in process.