What Health Problems Can Affect People Who Have a Fragile X Premutation?
People with premutation FMR1 genes do not have FXS. However, sometimes they have other symptoms, such as the following nervous system disorders, infertility, and problems with learning and behavior. • Fragile X-Associated Tremor / Ataxia Syndrome (FXTAS) FXTAS is a disorder of the nervous system that leads to tremors, problems with walking and balance (called ataxia), memory loss, and mood disorders. Studies have shown that at least 30% of men with the premutation who are older than 50 years of age develop FXTAS. Women who have a premutation are less likely to be affected by FXTAS, but if they develop FXTAS, it happens at a later age than in men. • Premature Ovarian Failure (POF) Normally, women will stop having menstrual cycles and experience menopause around 51 years of age. Women with premature ovarian failure (POF) stop having menstrual cycles and have symptoms of menopause before 40 years of age. POF occurs in about 1% to 4% of women in the general population; however, it occurs i
