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What is a permeability/performance reference compound (PRC) and how does it work?

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What is a permeability/performance reference compound (PRC) and how does it work?

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A PRC is an analytically non-interfering compound, such as certain perdeuterated PAHs, which has moderate-to-fairly high SPMD fugacity (escaping tendency). PRCs are added to the SPMD lipid before field studies and calibration exposures. Measured values of PRC loss rates are used to account for any rate affecting differences between field and calibration study (i.e., sampling rates measured under a specific set of conditions) exposure conditions. This approach to in situ SPMD calibration is based on the principle that the rate of residue loss is proportional to the rate of residue uptake. Thus, PRC loss rate data can be used to adjust SPMD-derived estimates of ambient concentrations to reflect site-specific environmental conditions of an exposure. Using the PRC method and previously developed models, SPMD based estimates of ambient water concentrations are within 2 fold of separately measure values.

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