What is a uPA + PAI-1 Breast Cancer Tumor Marker Test?
What is a uPA + PAI-1 Breast Cancer Tumor Marker Test?After an initial diagnosis of breast cancer, your doctor will need to know as much as possible about the type and nature of your tumor. Your doctor may order a tumor marker test, uPA + PAI-1, to help determine what treatment is best for you.Answer: A urokinase plasminogen activator (uPA) and PAI-1 test is a prognostic test that is done on a sample of tissue that is taken from a breast cancer tumor. The results of this test will tell your doctor if your cancer is aggressive and what your risk of recurrence may be. About Urokinase Plasminogen Activator (uPA) Urokinase is an enzyme that occurs naturally in your urine and blood plasma. It is produced in your kidneys, and helps dissolve blood clots in your kidneys or bladder. Tumors can also produce urokinase, and researchers think that it may encourage tumor cells to spread. Plasminogen is a substance that, when activated, becomes plasmin, an enzyme that digests fibrin, an insoluble pro