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What is an antagonist and how does it work to treat opioid dependence?

April 26, 2017antagonist dependence opioid treat

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What is an antagonist and how does it work to treat opioid dependence?

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An antagonist is a drug that blocks opioids from acting on the brain. Naltrexone, an opioid receptor antagonist, is used to treat both opioid and alcohol dependence. Because naltrexone temporarily blocks the effects of opioids but does not affect craving, its use to treat opioid dependence is limited. Buprenorphine also has some antagonist actions in the brain.