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What is an oncogene?

April 26, 2017oncogene

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What is an oncogene?

1 Answer

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10 Posted

An oncogene is a gene that causes cancer. Proto-oncogenes exist in cells and their normal function is in controlling cell division and cell growth. When a proto-oncogene is mutated, it becomes an oncogene and is no longer able to regulate cell growth. While the normal gene (proto-oncogene) can turn cell division and growth on or off, the mutant gene (oncogene) is stuck in the perpetually on position and cells continue to grow even when they should stop. Oncogenes act in a dominant fashion; only one copy needs to be mutated to observe uncontrolled growth. Oncogenes are analogous to driving a car with the accelerator permanently pressed.