What is better for treating wrinkles: Collagen or Hyaluronic Acid?

It depends on the location and depth of the wrinkle, among other things! Recently, many physicians who treat patients regularly with skin fillers have been using collagen-based fillers less. Fillers which contain hyaluronic acid are more commonly used these days. Examples include Restylane, Juvederm and Perlane. I use hyaluronic acid fillers virtually every day in my office. Collagen fillers have been available for over 20 years, first as Zyderm, then more recently as Cosmoderm, which does not require skin testing like Zyderm does. Zyderm 1 has the thinnest consistency. Zyderm 2 has a greater “thickness”, and Zyplast is the thickest collagen-based filler of the Zyderm family. Results with Zyderm and Cosmoderm last for about 3-4 months. In many treatment areas, hyaluronic acid fillers will last 6-9 months, sometimes even longer. When used to increase lip volume, however, these fillers may last only 4-6 months. We’re moving our mouths a lot during the day, and, as a result, the filler ...  more