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What is hereditary papillary renal cell carcinoma?

April 26, 2017carcinoma CELL hereditary papillary renal

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What is hereditary papillary renal cell carcinoma?

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Hereditary papillary renal cell carcinoma (HPRCC) is a hereditary condition that increases the risk of the papillary type of renal cell carcinoma (kidney cancer). There are two types of papillary renal cell tumors: type 1 and type 2. The tumors in HPRCC are type 1 tumors. Individuals with HPRCC have an increased risk of multiple kidney tumors and an increased risk of developing tumors on both kidneys. Currently, no other types of cancer or noncancerous health problems are known to be related to HPRCC. What causes HPRCC? HPRCC is a genetic condition. This means that the risk for type 1 papillary renal cell carcinoma can be passed from generation to generation in a family. Mutations (alteration) in a gene called c-met are linked to HPRCC development. C-met is a gene that encodes for the receptor to hepatocyte growth factor. Research is ongoing to learn more about HPRCC. How is HPRCC inherited? Normally, every cell has two copies of each gene: one inherited from the mother and one inherit