Lotemax is a topical steroid eye drop. Like Restasis, Lotemax decreases inflammation in the lacrimal glands and other ocular tissues. Unlike Restasis, Lotemax is a fast acting eye drop that instantaneously decreases inflammation. The combination of the fast acting mode of action by Lotemax combined with the long lasting effect of Restasis has been shown to work faster than the two medications independently. Since Lotemax is a steroid and must be monitored if taken long term, it is typically discontinued after Restasis has started showing therapeutic progress.