What is nefazodone?


Nefazodone is a relatively new antidepressant with a chemical structure that is somewhat similar to that of the phenylpiperazine antidepressant, trazodone. The antidepressant action of nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. Nefazodone does not have a chemical structure similar to the SSRIs, tricyclic anti- depressants, monoamine oxidase inhibitors, bupropion, or venlafaxine.