What is the antidote to warfarin?
Reversal can be achieved by stopping warfarin or administration of vitamin K, fresh frozen plasma or coagulation factor concentrates such as prothrombin complex concentrate (PCC). Complete reversal of anticoagulation may be life-saving. Fresh frozen plasma (FFP) and vitamin K are most frequently administered. However, there are surprisingly few studies defining the optimum dose of these products and there are no randomized studies comparing the relative benefit and risk of coagulation factor concentrates versus fresh frozen plasma.