What is the best self defense round for the .45?
This answer is subjective and has more than one simple answer. Many carry hollow point over full metal jacket FMJ. The best you can get with a hollow point is good expansion and prevention of over penetration IE exiting the target. Worst case is it won’t expand, which is no worse off then than the FJM bullet. I carry Remington Golden Saber JHP in 180 gr bullets, standard velocity. I have tested these at my home range and they do an excellent job of expansion even through layers of cloth.