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What is the clinical relevance of Factor V R2 mutation?

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What is the clinical relevance of Factor V R2 mutation?

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R2 (A4070G) is a mild factor V mutation believed to confer additional APC resistance when it is present in individuals who are heterozygous for FVL (R506Q). By itself, the R2 mutation does not significantly contribute to venous thrombosis risk.

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