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What is the difference between Provera (or any synthetic progestin) and Natural Progesterone?

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What is the difference between Provera (or any synthetic progestin) and Natural Progesterone?

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Pharmaceutical progestins do not appear in the biosynthetic pathway. The fact is, they are not found in any living forms. Furthermore, being foreign to all living things, they are patentable and thereby potentially more profitable.

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