What is the dissolution of Os-Cal?
The USP (United States Pharmacopaeia) has established a dissolution standard for calcium carbonate (which is used in Os-Cal) of at least 75% dissolved in 30 minutes. The mean percent dissolution for Os-Cal 500 tablets in one experiment was 87.6% in 30 minutes and 95.7% in 60 minutes. Although our products met the standards, many calcium supplements did not. In fact, dissolution and disintegration tests are performed on every batch of Os-Cal to make sure it meets USP standards. Many people have contacted us after conducting their own “experiments” with Os-Cal by dropping the tablets in a vinegar solution. Our laboratory advises that acetic acid (which is typically found in vinegar) would not be expected to readily dissolve Os-Cal tablets. It is difficult to replicate the contents and conditions of the stomach to provide a realistic comparison.
