What is the DNT Data Call-in?
• In August 1999, EPA informed the public that it was issuing data call-in notices to registrants of organophosphate pesticides. The data call-in would require submission of data on developmental neurotoxicity. Developmental neurotoxicity studies look at the way a pesticide affects the developing nervous system. Recent improvements in the basic study design coupled with refinements tailored on a case-by-case basis for each individual chemical will enhance the value of these data. EPA also is requiring additional data from acute and subchronic neurotoxicity screening studies. EPA, as always, supports the combining of study types, where possible, to maximize the amount of information gathered while minimizing animal testing. The developmental neurotoxicity study and the acute and subchronic neurotoxicity screens all lend themselves to being integrated into other study types. The results of the developmental and adult neurotoxicity testing in organophosphate pesticides are expected in 200
