What is the Effectiveness of Drug, Diet, Exercise, and Combination Therapy for Treating Dyslipidemia in Children/adolescents?
Statins and bile acid binding resins are effective for reducing TC and LDL-C in children with FH, the only population for whom they have been studied. These trials might not generalize to children without FH. Trials of other agents are methodologically limited. Diet supplements (psyllium, oat, sterol margarine) and counseling are marginally effective in lowering lipid levels in children with FH or FCH, as well as in children with idiopathic (risk factor associated) dyslipidemia. Trials show minimal if any improvement in lipids with exercise among children from the general population (overweight or normal weight). No trials evaluate exercise treatments in children with FH.
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