What is the FDA-approved indication for LYRICA?
• diabetic peripheral neuropathy (DPN) • postherpetic neuralgia (PHN) LYRICA is also indicated for the management of Fibromyalgia and is approved for adjunctive treatment of partial onset seizures in adults. Q2: What is neuropathic pain? A2: Neuropathic (or nerve) pain is pain caused by nerve damage or dysfunction in the central nervous system. A number of pathophysiological mechanisms may be responsible for neuronal hyperexcitability leading to neuropathic pain. These may include overexpression or abnormal activity of sodium channels, N-methyl-D-aspartate (NMDA) glutamate receptors, or other ion channels. The underlying mechanisms that cause neuropathic pain are different from those that cause musculoskeletal pain, such as arthritis or other pain due to tissue injury. Because of this, medications that prove effective for arthritis or other muscle pain may not relieve nerve pain.1 Q3: How does painful DPN present? A3: Painful DPN is characterized as burning, tingling, sharp, stabbing,