What is the LD50 for acetaminophen in people?
The Lethal Dose 50 (LD50) test involves the administration of a substance to a group of animals at increasing doses in order to determine the dose that kills 50 percent of the test subjects within a set time frame. As defined here: http://safe2use.net/ca-ipm/00-07-05a.htm “In adults, single doses above 10 grams or 140 mg/kg have a reasonable likelihood of causing toxicity. In adults, single doses of more than 25 grams have a high risk of lethality.” http://www.druglib.com/activeingredient/acetaminophen The LD50 of acetaminophen is pretty high — I came across a bunch of conflicting estimates, but it looks like somewhere in the neighborhood of 800 milligrams per kilogram (2.2 pounds) of body weight …