What is the margin of safety from having systemic effects due to minoxidil when dosing with Xandrox15-PLUS daily?

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What is the margin of safety from having systemic effects due to minoxidil when dosing with Xandrox15-PLUS daily?

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A. Minoxidil requires a serum concentration of 20 ng/mL to have any hemodynamic or other systemic effect in the human body. Allowing for the average 1.4% absorption (range 0.3 – 4.5%) of minoxidil from the topical application of 1 mL of Xandrox15-PLUS, there will be a serum concentration of minoxidil of ~4 ng / mL of minoxidil in the serum. So, there is an estimated 5-fold safety margin from any systemic effects of minoxidil due to the use of Xandrox15-PLUS, when it is used once/day as recommended. For optimal results, it is suggested that topical minoxidil be applied twice/day. One dose should be 1mL Xandrox15-PLUS and the second dose, at least 8 hours apart, should be 1mL of the lower concentration Xandrox 5% or 5% Minoxidil.

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