What is the most convenient and cost effective way to travel from Tokyo to Osaka with luggage?

The train is the best way for you to make this trip (as opposed to bus or car). This link will give you a brief overview (including costs): http://wikitravel.org/en/Osaka#Get_in This link will give you actual routes and further explanation about the Japanese rail pass: http://www.japan-guide.com/e/e2018.html My conclusion: The Nozomi train offers the best solution for you at 14050 JPY (or USD $143.00) and only 2 hours and 15 minutes travel time.  more