What is the most important information I should know about glyburide and metformin?
• A small number of people who have taken metformin have developed a serious condition called lactic acidosis that has been fatal in up to 50% of cases. Lactic acidosis has occurred most often in people whose kidneys were not working properly. Liver problems may also increase the risk of developing lactic acidosis. Stop taking glyburide and metformin and call your doctor immediately if you experience a feeling of general discomfort or sickness; weakness; sore or aching muscles; trouble breathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplained stomach upset (after the initial stomach upset that may occur at the start of therapy with glyburide and metformin); or the sudden development of a slow or irregular heartbeat. These may be signs of lactic acidosis. • Avoid excessive alcohol intake while taking glyburide and metformin. Together, alcohol and glyburide and metformin may increase the risk of lactic acidosis and hypoglycemia. • Know the signs and symptoms of
