What is the pathogenesis of type 2 diabetes mellitus?
The insulin-secreting cells of Type 2 diabetes mellitus (NIDDM) are damaged slightly and some even accrete, therefore, the insulin secretion is normal or higher, however, the insulin secretion is lower by sugar stimulation comparing with non-diabetic patients of the similar weight, indicating the potential inactiveness of insulin-secreting cells, namely, relative insufficient of insulin activity. The obesity and overweight are easier to get type 2 diabetes, shown as hyperinsulinemia, thats because too much insulin is secreted by patient’s B-cells as the long-term stimulation of high blood sugar. The relative or absolute overabundance of proglucagon, which only happens to patients with a serious lack of insulin or ketoacidosis patients of poor control. In these cases, if enough insulin is applied, the proglucagon will be restrained, therefore, the pathogenesis of diabetes is the insufficient of insulin. The insulin-secreting cells of Type 2 diabetes mellitus (NIDDM) are damaged slightly
