What is the science that ties nutritional supplementation and lifestyle changes to the predisposition marked by the SNPs?

Leading clinical evidence is increasingly linking SNPs to specific nutritional needs. For example: The SNP for methylenetetrahydrofolate reductase (MTHFR) produces an enzyme with decreased affinity for its direct substrate, 5,10 methylene-THF, which can cause a build-up of homocysteine. In plain English, it means that some people make more homocysteine than others, and now you are able find out if this applies to your patients. Those who make more homocysteine would especially benefit by increasing folate in their diet, as well as starting dietary supplements that are clinically shown to reduce homocysteine. Another example concerns individuals with the SNP for paraoxonase-1 (PON-1) who have an enhanced propensity for superior cardiac health because they more effectively block oxidation of LDL cholesterol. This means these people will have less oxidized LDL cholesterol than others. This SNP can also determine how effective vitamin C and vitamin E are as antioxidants in specific ...  more