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What is the significance of HLA B27 in rheumatic disease?

April 26, 2017b27 disease HLA rheumatic significance

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What is the significance of HLA B27 in rheumatic disease?

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HLA B27 is an inherited gene marker associated with a number of related rheumatic diseases. This gene is found with highest prevalence in patients with ankylosing spondylosis (>90%), reactive arthritis (80%), and patients with the combination of peripheral arthritis and either psoriasis or inflammatory bowel disease (50%).