What is the significance of lobular carcinoma in-situ (LCIS) in terms of prognosis and treatment?
The presence of LCIS increases the risk of subsequently developing carcinoma in both breasts. Typically, LCIS found on excision is managed with observation, and in some cases, with hormone therapy. In some cases where LCIS is found on needle biopsy, surgical excision may be recommended if the LCIS does not account for the mammographic findings or if the LCIS is pleomorphic or has necrosis (see FAQ 13). The appropriate treatment of LCIS found on needle biopsy is an area of uncertainty and is best discussed with your treating physician.
