What is the Significance of Superinfection in HIV Transmission?
Superinfection is defined as infection by a second strain of HIV after initial infection by a primary strain has been established [44]. The frequency and timing of superinfection may vary depending upon the population under study and the method of detection. Follow-up of 78 newly infected individuals (none of whom initiated ART while under study) in one clinic revealed that 4 (5%) had acquired a superinfecting strain within 6 to 12 months of initial infection [45]. In a cohort of 36 high-risk Kenyan women screened for HIV-1 superinfection over a 5-year period beginning at primary infection, seven cases of superinfection were detected [46]. In this study superinfection occurred throughout the course of the first infection: during acute infection in two cases, between 1-2 years after infection in three cases, and as late as 5 years after infection in two cases. The clinical consequences of superinfection for an individual vary, but may include accelerated disease progression and the acqu
