What is the “T” in the structure of thiol-modifier C6?
RESPONSE:”T” is short for trityl or triphenylmethyl. This group is not significantly acid labile and requires an oxidative cleavage with silver nitrate to remove it. It is also susceptible to oxidative cleavage with the iodine oxidizer and, for maximum yield, the iodine concentration in that oxidizer should be 0.02M, which is now virtually standard. REFERENCE(S): Glen Research User Guide to Modification and Labelling, 1999, 24.