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What model of auto-immunity may be involved in the pathogenesis of tic disorders?

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What model of auto-immunity may be involved in the pathogenesis of tic disorders?

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Over the past decade a significant amount of research has been conducted on the role of autoimmunity in tic disorders. The proposed model of pathogenesis of tic disorders in this research is analogous to Sydenham’s Chorea.15 In genetically predisposed individuals, tics and associated phenomena are thought to arise as a consequence of the immunological response to infections with Group A beta hemolytic Streptococci (GABHS). Antibodies directed against the streptococci are hypothesized to cross-react with structures of the central nervous system, subsequently leading to damage to these structures, which eventually results in the emergence of tics and associated features. This mechanism of autoimmunity is supposed to be based on molecular mimicry between host and micro-organism.

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