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What percentage of red blood cells is removed during processing?

April 26, 2017PERCENTAGE red blood cells removed

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What percentage of red blood cells is removed during processing?

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The concentration of red blood cells left in the final product after processing is overlooked by less experienced cord blood banks. A study demonstrated that a high concentration of red blood cells (Hematocrit =0.36) can damage up to 1/3 of cord blood stem cells during cryopreservation (freezing). During optimal cryopreservation, ice only forms EXTRACELLULARLY and not intracellularly. Intracellular ice formation directly damages cord blood stem cells but extracellular ice only damages cells when the concentration of red blood cells is very high, causing what is known as “the packed effect.” With Progenics’ processing procedure, 94% of the red blood cells are removed, and the average hematocrit is 0.078(8%).