What precautions should I take when using leukotriene inhibitors?
Although leukotriene inhibitors are considered safe, they can raise the levels of liver enzymes. The FDA recommends liver function tests monthly for the first three months on medication, followed by quarterly monitoring for the next year, and continued interim testing. Zileuton is contraindicated for those with elevated liver enzymes, active alcoholism, or liver disease. Increased levels of liver enzymes may be detectable in the blood within two months of starting zileuton. Zileuton can affect liver function and, one rare occasions, can damage the liver. It is unclear whether leukotriene inhibitors should be taken during pregnancy. Zafirlukast and zileuton should not be used by a woman who is breastfeeding. Both medications have been found to increase the risk of mild to moderate respiratory tract infections in patients aged 55 and older. Medical conditions that may interfere with the use of montelukast include: allergies to aspirin or non-steroidal anti-inflammatories (NSAIDs); liver
