What research is NTP doing to address the possible human health risks associated with nanotechnology and nanoscale materials?
The NTP intends to conduct studies that test hypotheses focused on the relationship of key physicochemical parameters of selected manufactured nanomaterials to their potential toxicity. Initial parameters of greatest concern are size, shape, surface chemistry, and composition. This strategy will be accomplished by developing a suite of analytical approaches to evaluate and characterize the physiochemical properties of nanoscale materials in their raw form and as formulated when given to animals or exposed to cells in culture. In addition, we will conduct animal toxicity studies of varying durations with specific nanomaterials using routes of administration that mimic possible human exposure. These studies will include evaluations of the absorption and handling of the materials by rodents. We also intend to develop a battery of in vitro models to evaluate the biological and toxicological effects of nanoscale materials. These models would be used to assess whether in vitro methods can pr
