What safety information has been added to the label of Rituxan?
• Bowel obstruction (blockage of the small or large intestine) and bowel perforation (development of a hole in the small or large intestine) have been observed in patients receiving Rituxan. Some deaths have occurred in non-Hodgkin’s lymphoma patients who were receiving Rituxan. • A relationship between Rituxan and these events has not been clearly established. • The average time for Rituxan patients to develop bowel perforation was 6 days from the start of therapy. • Patients who experience abdominal pain, especially early in treatment, should contact their physician immediately. What is the most important safety information I should know about Rituxan? Serious side effects, some of which could be life threatening, have occurred during and after treatment with Rituxan. Seek immediate medical attention if you experience any of the following: • Infusion reactions, including hives, swelling, dizziness, blurred vision, drowsiness, headache, cough, wheezing, and breathing difficulties • Ki
