What type of evidence did FDA evaluate to arrive at their decision?
In making its decision to issue the order to prohibit the extralabel use of cephalosporins in food-producing animals, FDA considered a broad set of information, including scientific literature, antimicrobial resistance surveillance data collected as part of the U.S. National Antimicrobial Monitoring System (NARMS), antimicrobial resistance surveillance data collected in other countries, as well as unpublished data collected as part of FDA inspectional activities. Data collected as part of NARMS has shown a rise in resistance to ceftiofur, a third generation cephalosporin drug approved for use in animals, among Salmonella isolates from both humans and food-producing animals. Although ceftiofur is not used in human medicine, increasing resistance to this drug among animal and human isolates highlights concerns about the movement of foodborne bacteria between animals and humans. Furthermore, increasing resistance to particular cephalosporin drugs is of public health concern in light of ev
