What types of genetic monitoring testing does Charles River Genetic Testing Services offer?
Charles River Genetic Testing Services provides DNA-based testing to facilitate the periodic genetic monitoring of transgenic and knockout strains of laboratory animals. Charles River Genetic Testing Services employs the techniques of DNA amplification using both PCR (polymerase chain reaction) and real-time QPCR (quantitative PCR). In addition, Charles River Genetic Testing Services offers DNA profile testing using microsatellites for strain characterization and differentiation, maintenance of strain purity, and speed congenics (MAX-BAXSM). Our services include genotyping for a specific gene by PCR, SNP analysis, zygosity and expression testing using QPCR, and genome scans by microsatellite analysis. • MAX-BAXSM (Marker Assisted Accelerated Backcrossing) is used for the application of speed congenics. Candidate breeders are genotyped at each generation, and those with the highest percentage of the desired strain are selected to father the next generation. This can greatly reduce the n
