What Were the Results of the Human Health Risk Assessment?
The overall conclusion of the human health risk assessment is that “current exposure levels of BPA will not pose any unacceptable risk to human health.” This conclusion is based on a comprehensive review of the toxicological profile of bisphenol A combined with estimates of human exposure to bisphenol A. The exposure estimates were derived from two different methodologies. Key aspects of the human health assessment include: • A No-Observed-Adverse-Effect-Level (NOAEL) or Benchmark Dose Lower Limit (BMDL) was established for three key toxicological endpoints. All were in the range of 5-50 milligrams/kg-bodyweight/day. • For reproductive toxicity, a NOAEL of 50 milligrams/kg-bodyweight/day was established based on a comprehensive study that examined the effects of bisphenol A over the course of four generations of laboratory animals. (2) • Notably, findings from studies claiming reproductive effects at much lower doses were not considered to be robust in comparison to the consistent find
