When performing analysis using ICP and ICP-MS, what is the appropriate action when a sample value is greater than the highest calibration standard but within the linear dynamic range?
EDQW Response: QSM Box #53 states, “When sample concentrations exceed the upper limit of the calibration curve, samples shall be diluted and reanalyzed (if possible) to bring them within the calibration curve. When sample concentrations exceed the upper limit of the calibration curve or fall below the lower limit of the calibration curve, the resulting data shall be qualified as having estimated values and shall be flagged.” If results for a sample exceed the highest calibration standard then the sample must be diluted or the laboratory may elect to verify the instrumental response to + 10% by analyzing a standard with the same calibration that is within the defined linear “dynamic” range, but has a higher concentration than the sample. The DoD does allow non-target analytes to be quantified when they fall outside the calibration range but inside in the linear “dynamic” range without sample dilution.
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