A.) Methadone was originally developed by the Nazis during World War II. When the supply of opium was cut off, Nazi addicts like Hermann Goering (Commander in Chief of the Luftwaffe and Hitler's designated successor) wanted to avoid the possibility of withdrawal. He instructed the German drug companies to produce a wholly synthetic opiate that didn't need to rely on the poppy. The chemists came up with a drug that not only worked, but also lasted a long time. As a result, Methadone has become the drug of choice for doctors who are trying to help users manage their opiate dependency. Heroin wears off after a couple of hours, thus requiring several hits each day. Methadone, on the other hand, lasts anywhere between 24 and 72 hours, depending on the dose that you take and on your individual metabolism.