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Which antiplatelet drug is best for patients on PPIs?

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Which antiplatelet drug is best for patients on PPIs?

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A Paris-based clinical trial will set out to determine the efficacy of two antiplatelet drugs, prasugrel (Effient, Daiichi-Sankyo/Eli Lilly) or a double dose of clopidogrel (Plavix, Bristol-Myers Squibb/Sanofi Aventis), in coronary artery disease patients who are taking lansoprazole (Prevacid, Takeda), a proton-pump inhibitor (PPI). The study will split 104 patients into two arms: one will be administered 150 mg of clopidogrel (double dose) and the other arm will be administered prasugrel. The patients in each group will be administered either a placebo or lansoprazole. The researchers will then decipher whether lansoprazole is less likely to impair the efficacy of the antiplatelet drugs than other PPIs that have been shown to raise the risk of major cardiovascular events (MACE) and weaken the benefits of clopidogrel. Researchers from the Hospital Pitie’ Salpetriere’ in France will record patient data at baseline and at two weeks after they received lansoprazole. Additionally, they wil

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