Which patients should I consider for risk assessment and to discuss the option of genetic testing for BRCA1 and BRCA2 mutations?

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Which patients should I consider for risk assessment and to discuss the option of genetic testing for BRCA1 and BRCA2 mutations?

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Most individuals do not have a mutation in the BRCA1 or BRCA2 gene. While specific indications for genetic counseling and testing vary among professional organizations, certain aspects of your patient’s personal and/or family history may increase his or her likelihood of carrying a BRCA1 or BRCA2 mutation. The indications below are to be used as a guide and are not a substitute for clinical judgment. Not all clinical scenarios can be anticipated. For instance, genetic testing guidelines may not take into consideration a situation where the family history is limited.6 In addition, individual insurance companies have their own criteria for reimbursement for genetic testing that may not match the indications lists below.

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Most individuals do not have a mutation in the BRCA1 or BRCA2 gene. While specific indications for genetic counseling and testing vary among professional organizations, certain aspects of your patient’s personal and/or family history may increase his or her likelihood of carrying a BRCA1 or BRCA2 mutation. The indications below are to be used as a guide and are not a substitute for clinical judgment. Not all clinical scenarios can be anticipated. For instance, genetic testing guidelines may not take into consideration a situation where the family history is limited. 6 In addition, individual insurance companies have their own criteria for reimbursement for genetic testing that may not match the indications lists below.

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